Immunization with pentraxin 3 (PTX3) leads to anti-PTX3 antibody production and delayed lupus-like nephritis in NZB/NZW F1 mice
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- 作者：Mariele Gattoa ; Anna Ghirardelloa ; Roberto Luisettob ; Nicola Bassia ; Marny Fedrigoc ; Marialuisa Valentec ; Sonia Valentinod ; Dorella Del Pretee ; Leonardo Punzia ; Andrea Doriaa ; adoria@unipd.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anti-pentraxin 3 antibodies ; Lupus glomerulonephritis ; Complement activation ; Nephritogenic antibodies ; Survival
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：208-216
- 全文大小：1744 K
文摘
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Renal PTX3 deposition correlates with worse renal disease in lupus nephritis.
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Anti-PTX3 antibodies confirmed a protective role in murine lupus-like nephritis.
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Anti-PTX3 antibodies may hinder complement activation.
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IgG4 isotype may in part account for anti-PTX3 protective effect.