Metformin decreases serum 8-hydroxy-2¡ä-deoxyguanosine levels in polycystic ovary syndrome

详细信息    查看全文

• 作者：Henri Sova ; M.B.^a ; ^b ; ^{henrijuh@mail.student.oulu.fi} ; Ulla Puistola ; M.D. ; Ph.D.^b ; Laure Morin-Papunen ; M.D. ; Ph.D.^b ; Peeter Karihtala ; M.D. ; Ph.D.^a ; ^b
• 关键词：8-OHdG ; metformin ; oxidative stress ; polycystic ovary syndrome ; reactive oxygen species
• 刊名：Fertility and Sterility
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：99
• 期：2
• 页码：593-598
• 全文大小：178 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferencesml version=""1.0"" encoding=""UTF-8""?>

Objective

To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2¡ä-deoxyguanosine (8-OHdG).

Design

Double-blind, randomized, placebo-controlled trial.

Setting

University outpatient clinic.

Patient(s)

The study cohort consisted of 50 obese women (body mass index [BMI] ¡Ý27 kg/m²) and 60 nonobese patients (BMI <27 kg/m²), mean age was 27.7 ¡À 4.0 SD years.

Intervention(s)

Randomization to receive metformin or placebo for 3 months.

Main Outcome Measure(s)

Serum levels of 8-OHdG before and after medical treatment.

Result(s)

The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates.

Conclusion(s)

Metformin treatment, compared with placebo, statistically significantly decreased 8-OHdG levels in women with polycystic ovary syndrome.

Clinical Trial Registration Number

.