Chloride conducting light activated channel GtACR2 can produce both cessation of firing and generation of action potentials in cortical neurons in response to light

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• 作者：A.Y. Malyshev^a ; ^{malyshev@ihna.ru} ; M.V. Roshchin^a ; G.R. Smirnova^a ; D.A. Dolgikh^b ; ^d ; P.M. Balaban^a ; ^c ; M.A. Ostrovsky^c ; ^e
• 关键词：Optogenetics ; Light-activated chloride channel ; Pyramidal neuron ; Inhibition ; Action potential ; Distant initiation
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：640
• 期：Complete
• 页码：76-80
• 全文大小：952 K
• 卷排序：640

文摘

Light activated chloride channel GtACR2 was expressed in vivo in rat pyramidal neurons. Light stimulation of GtACR2 can induce both inhibition and excitation of cells. Light-induced generation of action potentials most likely occurs in axonal terminals. GtACR2 potentially could be used both as cell silencer and cell activator in optogenetics experiments.