Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model
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- 作者：Adhithiya Charli ; Huajun Jin ; Vellareddy Anantharam ; Arthi Kanthasamy ; Anumantha G. Kanthasamy ; akanthas@iastate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tebufenpyrad ; Pyridaben ; Pesticides ; Neurotoxicity ; Mitochondrial dysfunction ; Oxidative stress ; Seahorse
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：302-313
- 全文大小：3174 K
文摘
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Tebufenpyrad (TF) and pyridaben (PY) are dose-dependently toxic in dopaminergic neuronal cells.
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TF and PY impair mitochondrial respiration, O2 consumption and ATP production.
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TF and PY induce severe mitochondrial structural abnormalities.
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Oxidative damage underlies TF- and PY-induced dopaminergic neurotoxicity.