Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda
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- 作者：Fredrick Kateeraa ; b ; fkkateera@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; fkateera2011@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sam L. Nsobyac ; d ; snsobya@idrc-uganda.org" class="auth_mail" title="E-mail the corresponding author ; Steven Tukwasibwec ; stephentukwasibwe@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Emmanuel Hakizimanaa ; e ; ehakizimana@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Leon Mutesaf ; lmutesa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Petra F. Mensb ; g ; p.mens@kit.nl" class="auth_mail" title="E-mail the corresponding author ; Martin P. Grobuschb ; m.p.grobusch@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; Michè ; le van Vugtb ; m.vanvugt@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; Nirbhay Kumarh ; nkumar@tulane.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plasmodium falciparum ; Chloroquine ; Sulfadoxine-pyrimethamine ; Resistance ; Polymorphisms
- 刊名：Acta Tropica
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：329-336
- 全文大小：1332 K
文摘
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Antimalarial drugs chloroquine and sulphodoxine − pyrimethamine resistance was a setback to malaria control.
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Studies reveal that withdrawal of there can lead to recovery of sensitivity of parasites over time.
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In Rwanda chloroquine susceptibility recovery appears slow but sulphodoxine − pyrimethamine resistance remains high after years of withdrawal.
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Elucidating the determinants of these drug-related genomic adaptations over time and exposure to varying drug pressures in Rwanda is needed.