Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents

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• 作者：Christophe Labriè ; re^a ; ¹ ; ^{christophe.labriere@gmail.com} ; Huansheng Gong^b ; B. Brett Finlay^b ; ^c ; Neil E. Reiner^b ; ^d ; Robert N. Young^a ; ^{roberty@sfu.ca}
• 关键词：Methicillin-resistant Staphylococcus aureus ; Antimicrobial ; Pyruvate kinase inhibitor ; Structure&ndash ; activity relationships
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：1-13
• 全文大小：2546 K
• 卷排序：125

文摘

MRSA pyruvate kinase (PK) was identified as a novel antimicrobial target. MRSA PK inhibitors of the hydrazide family were previously identified. Novel series of inhibitors were synthesized: 3-, 2- and 0-atom(s) linkers.