Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells
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- 作者：Tingfen Zhanga ; Qiang Zhangb ; Jiabin Guoa ; Haitao Yuana ; Hui Penga ; Lan Cuia ; Jian Yina ; Li Zhanga ; Jun Zhaoa ; Jin Lic ; Andrew Whitec ; Paul L. Carmichaelc ; Carl Westmorelandc ; Shuangqing Penga ; pengsq@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：APAP ; acetaminophen ; GSH ; glutathione ; LDH ; lactate dehydrogenase ; mtDNA ; mitochondrial DNA ; MPT ; mitochondrial permeability transition ; MnSOD ; manganese superoxide dismutase ; NAPQI ; N-acetyl-P-benzoquinoneimine ; ND1 ; nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 1 ; NRF-1 ; nuclear respiratory factor 1 ; Nrf2 ; nuclear erythroid-2 like factor-2 ; PGC-1α ; peroxisome proliferator-activated receptor γ coactivator-1α ; SIRT1 ; silentmating type-information regulation 2 homolog 1 ; ROS ; rea
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：71-79
- 全文大小：1740 K
文摘
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Non-cytotoxic concentration of APAP induced mitochondrial biogenesis in HepG2 cells.
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The heightened biogenesis concurred with induction of PGC-1α, NRF-1 and TFAM genes.
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GSH and antioxidant genes were also induced by non-cytotoxic concentration of APAP.
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The above two groups of genes were downregulated at cytotoxic concentration of APAP.
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Mitochondrial biogenesis and antioxidant response could protect liver from APAP.