Two new steroidal glycosides with unique structural feature of 14α-hydroxy-5β-steroids from Reineckia carnea

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• 作者：Ju-Yan Zheng ; Qian Wang ; Zhao-Xia L\iu ; Cheng-Xiong Liu ; ^{liuchengxiong666@126.com} ; Zhi-Yong Guo ; Hong-Qi Zhang ; Hai-Bo He ; Xuan Tu ; Kun Zou
• 关键词：Reineckia carnea ; Steroidal glycosides ; NMR ; Structural elucidation ; Anticancer activity
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：115
• 期：Complete
• 页码：19-23
• 全文大小：484 K
• 卷排序：115

文摘

Two new steroidal glycosides (1–2) were isolated from the roots of Reineckia carnea, together with three known compounds (3–5). Their structures were determined on the basis of chemical methods and spectral data. Compounds 1–2 were the unique steroidal glycosides possessing structural feature of 14α-hydroxy-5β-steroids, and compounds 4–5 were isolated from R. carnea for the first time. The isolated compounds (1–5) were tested in vitro for their cytotoxic activities against the A549, HepG 2 and Caski cancer cell lines. Among them, the compounds 2 and 3 showed cytotoxicity against Caski cancer cell line with IC50 values of 34.4 and 3.7 μM, respectively.