Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway
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- 作者：Tingting Qin ; Fang Fang ; Meiting Song ; Ruipeng Li ; Zhanqiang Ma ; mazhanqiang0427@163.com" class="auth_mail" title="E-mail the corresponding author ; Shiping Ma ; spma@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROCK ; Rho-associated protein kinase ; Akt ; protein kinase B ; PTEN ; phosphatase and tensin homolog ; GSK3β ; glycogen synthase kinase 3β ; CUMS ; chronic unpredictable mild stress ; CMC-Na ; carboxymethyl cellulose ; IL-1β ; interleukin 1β ; IL-6 ; interleukin 6 ; TNF-α ; tumour necrosis factor α ; ELISA ; enzyme-linked immunosorbent assay ; Umb ; umbelliferone ; Fas ; fasduil ; SPT ; sucrose preference test ; OFT ; open field test ; FST ; forced swimming test
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：147-156
- 全文大小：3810 K
文摘
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Umbelliferone ameliorates CUMS-induced depressive-like behavior.
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Umbelliferone protects neurons by preventing neuronal apoptosis.
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The antidepressant-like effects of umbelliferone are achieved by regulating ROCK/Akt pathway.
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