Hyperthermia exacerbates the effects of cathepsin L on claudin-1 in a blood-brain barrier model in vitro
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- 作者：Conghua Jia ; 1 ; Limin Wanga ; 2 ; Rongrong Daib ; Li Shana ; Hui Yangc ; Hongyan Zhud ; Qiang Menge ; mq301@sina.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Brain microvascular endothelial cells ; Astrocytes ; Blood-brain barrier ; Hyperthermia ; Cathepsin L ; Claudin-1
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1631
- 期：Complete
- 页码：72-79
- 全文大小：1666 K
文摘
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A blood-brain barrier model in vitro was made.
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Evaluate the effect of cathepsin L on claudin-1 expression under hyperthermic condition.
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Cathepsin L can reduce claudin-1 in brain microvascular endothelial cells in vitro.
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Hyperthermia decrease claudin-1 by upregulating cathepsin L in astrocytes.