Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
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- 作者：Baoli Hu1 ; 16 ; Qianghu Wang2 ; 3 ; 16 ; Y. Alan Wang1 ; 16 ; yalanwang@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Sujun Hua1 ; Charles-Etienne Gabriel Sauvé ; 1 ; Derrick Ong1 ; Zheng D. Lan1 ; Qing Chang3 ; 9 ; Yan Wing Ho1 ; Marta Moreno Monasterio1 ; Xin Lu1 ; Yi Zhong4 ; Jianhua Zhang3 ; 9 ; Pingna Deng1 ; Zhi Tan5 ; Guocan Wang1 ; Wen-Ting Liao1 ; Lynda J. Corley6 ; Haiyan Yan10 ; Junxia Zhang11 ; Yongping You11 ; Ning Liu11 ; Linbo Cai12 ; Gaetano Finocchiaro13 ; Joanna J. Phillips14 ; Mitchel S. Berger15 ; Denise J. Spring1 ; Jian Hu1 ; Erik P. Sulman7 ; 8 ; Gregory N. Fuller6 ; Lynda Chin3 ; Roeland G.W. Verhaak2 ; 3 ; Ronald A. DePinho1 ; 17 ; rdepinho@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：glioblastoma ; cancer stem cell differentiation ; tumor microenvironment ; recurrence
- 刊名：Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：167
- 期：5
- 页码：1281-1295.e18
- 全文大小：13477 K
文摘
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Comparisons of NSCs and derivative GSCs reveal elevated WNT5A and EC signature
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PAX6/DLX5 bidirectionally regulates WNT5A during differentiation of GSCs into GdECs
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WNT5A-mediated GdEC differentiation and EC recruitment support GSC invasive growth
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Clinical studies of peritumoral/recurrent GBM reveal increased WNT5A/GdEC expression