Over-expression of microRNA-375 inhibits papillary thyroid carcinoma cell proliferation and induces cell apoptosis by targeting ERBB2

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• 作者：Xin-Zheng Wang^a ; ^{xinzheng_w@126.com" class="auth_mail" title="E-mail the corresponding author} ; Ya-Kai Hang^b ; Jin-Biao Liu^a ; Yong-Qiang Hou^a ; Ning Wang^a ; Ming-Jun Wang^a
• 关键词：MicroRNA-375 ; Papillary thyroid carcinoma ; ERBB2 ; Apoptosis
• 刊名：Journal of Pharmacological Sciences
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：130
• 期：2
• 页码：78-84
• 全文大小：1152 K

文摘

MicroRNAs (miRs) played important roles in the cell proliferation, apoptosis and other biological processes in cancer. In the present study we found that miR-375 was significantly down-regulated in human papillary thyroid carcinoma (PTC) tissues and cell lines. In this study we try to investigate the biological activity of miR-375 in human PTC cells and try to find the potential target of miR-375. Our study indicated that over-expression of miR-375 could inhibit the PTC cells proliferation and this inhibition was caused by the induction of cell apoptosis. In vivo animal study indicated that over-expression of miR-375 could significantly decrease the migration and invasion of human PTC cell in vivo. These results exhibit over-expression of miR-375 in human PTC cells could inhibit the process of human PTC. Further study demonstrated ERBB2 was a direct target of miR-375, over-expression of miR-375 decrease the both mRNA and protein expression of ERBB2 in human PTC cells. These data indicate miR-375 play important roles in the process and development of human PTC. These finds suggested that appropriate application of miR-375 regulation might be a new sight for the treatment of human PTC in the future.