Inhibition effect of cypermethrin mediated by co-regulators SRC-1 and SMRT in interleukin-6-induced androgen receptor activation
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- 作者：Qi Wang ; Ji-Long Zhou ; Hui Wang ; Qiang Ju ; Zhen Ding ; Xiao-Long Zhou ; Xing Ge ; Qiao-Mei Shi ; Chen Pan ; Jin-Peng Zhang ; Mei-Rong Zhang ; Hong-Min Yu ; Li-Chun Xu ; lichunxu2002@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cypermethrin ; Anti-androgen ; Androgen receptor ; Steroid receptor co-activator-1 ; Silencing mediator for retinoid and thyroid hormone receptors ; Interleukin-6
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：24-29
- 全文大小：709 K
文摘
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Cypermethrin can inhibit IL-6-mediated AR activation in androgen-independent manner.
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Cypermethrin represses IL-6-induced cell growth using the RTCA iCELLigence system.
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Cypermethrin suppresses the interaction between AR NTD and co-activator SRC-1 induced by IL-6.
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Cypermethrin suppresses the interaction between AR NTD and co-repressor SMRT induced by IL-6.
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