Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling
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- 作者：Bin Liua ; 1 ; iamicehe@163.com" class="auth_mail" title="E-mail the corresponding author ; Bo Caob ; c ; 1 ; caobo19814@126.com" class="auth_mail" title="E-mail the corresponding author ; Di Zhangd ; 1 ; zhangdibad@163.com" class="auth_mail" title="E-mail the corresponding author ; Na Xiaoa ; Hong Chenb ; Guo-qiang Lia ; Shou-chun Penga ; Lu-qing Weia ; luqing-wei@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Paraquat ; Salvianolic acid B ; Pulmonary fibrosis ; Nrf2 ; NOX4 ; TGF-β1/Smad3 signaling pathway
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：309
- 期：Complete
- 页码：111-120
- 全文大小：2913 K
文摘
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Salvianolic acid B (SalB) reduced Paraquat-induced mortality and pulmonary injury in mice.
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SalB has anti-oxidation, anti-inflammatory and anti-fibrogenic effects simultaneously.
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Its mechanisms were targeting Nrf2-Nox4 redox balance and TGF-β1/Smad3 signaling.