Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response
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- 作者：Mei Qia ; Yao Danga ; Qinglong Xua ; Liqin Yua ; b ; Chunsheng Liua ; b ; c ; Yongchao Yuana ; Jianghua Wanga ; b ; whtjwjh@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microcystin ; Developmental toxicity ; Endoplasmic reticulum ; Stress ; Zebrafish
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：166-173
- 全文大小：1073 K
文摘
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MCLR induced activation of ER stress which consequently triggered apoptosis in zebrafish larvae.
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MCLR could activate MAPK8/Bcl-2/Bax pathway and caspase-dependent apoptotic pathway in zebrafish larvae.
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Effects of MCLR on zebrafish larvae could be prevented by treatment with inhibitor of ER stress, TUDCA.
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