Rb selectively inhibits innate IFN-β production by enhancing deacetylation of IFN-β promoter through HDAC1 and HDAC8
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- 作者：Jun Menga ; 1 ; Xingguang Liub ; 1 ; Peng Zhangb ; Dong Lic ; Sheng Xub ; Qingqing Zhoub ; Meng Guob ; Wanwan Huaia ; Xiang Chenb ; Quanxing Wangb ; Nan Lib ; Xuetao Caoa ; b ; d ; caoxt@immunol.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Retinoblastoma protein ; Innate immunity ; IFN-β ; Histone deacetylase ; Inflammation
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：42-53
- 全文大小：2834 K
文摘
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Rb-deficient mice produce more type I IFN with resistance to virus infection.
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Rb selectively inhibits the innate IFN-β production in macrophages.
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Rb binds Ifnb1 enhancer region through c-Jun and suppresses Ifnb1 gene transcription.
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Rb recruits HDAC1 and HDAC8 to Ifnb1 promoter to induce histone H3/H4 deacetylation