The synthesis and characterization of a novel biodegradable and electroactive polyphosphazene for nerve regeneration

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• 作者：Qingsong Zhang ; Yuhua Yan ; Shipu Li ; Tao Feng
• 关键词：Biodegradability ; Biomedical material ; Electroactivity ; Oligoaniline ; Polyphosphazenes
• 刊名：Materials Science and Engineering: C
• 出版年：2010
• 出版时间：1 January 2010
• 年：2010
• 卷：30
• 期：1
• 页码：160-166
• 全文大小：1810 K

文摘

Conductive polymers have been of great interest to the biopharmaceutical industry because of their cell adhesion and proliferation. In this paper, a novel electrically-conductive and biodegradable polyphosphazene polymer containing parent aniline pentamer (PAP) and glycine ethyl ester (GEE) as side chains was synthesized through a nucleophilic substitution reaction for its potential application in nerve regeneration. The electrical conductivity of the polymer was ~ 2 × 10^− 5 S/cm in the semiconducting region upon preliminarily protonic-doped experiment. Degradation studies carried out in phosphate-buffered saline at 37 °C showed a mass loss of ~ 50 % after 70 days. In vitro cytotoxicity to the RSC96 Schwann cells was evaluated using the cell viability assay. The polymer exhibited no cytotoxicity, indicating that such a polyphosphazene polymer has potential as scaffold material in tissue engineering for peripheral nerve regeneration or other biomedical devices that require electroactivity.