A novel Zn²⁺ complex as the ratiometric two-photon fluorescent probe for biological Cd²⁺ detection

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• 作者：Weipeng Ye ; Shuxing Wang ; Xiangming Meng ; Yan Feng ; Hongting Sheng ; Zonglong Shao ; Manzhou Zhu ; Qingxiang Guo
• 关键词：Ratiometic ; Two-photon ; Fluorescent probe ; Zn2+ complex ; Cd2+ ; Bio-imaging
• 刊名：Dyes and Pigments
• 出版年：February, 2014
• 年：2014
• 卷：101
• 期：Complete
• 页码：30-37
• 全文大小：1711 K

文摘

A novel Zn²⁺ complex as the ratiometric two-photon fluorescent probe (HQZn) for Cd²⁺ detection was synthesized. Fluorescence emission spectra of the probe showed a large red-shift (75聽nm) and obvious enhancement of fluorescent intensity upon the addition of Cd²⁺. HQZn shows high selectivity for Cd²⁺ over other metal ions, and can eliminate the interference of Zn²⁺ during Cd²⁺ detection. Maldi-TOF MS spectra indicated that the response of HQZn to Cd²⁺ was caused by central metal displacement. Cell cytotoxicity and bio-imaging studies revealed that HQZn was cell-permeable and it could be used to detect intracellular Cd²⁺ with low cytotoxicity under two-photon excitation.