Strategies of polymeric nanoparticles for enhanced internalization in cancer therapy
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- 作者：Lu Sun ; Qinjie Wu ; Feng Peng ; Lei Liu ; Changyang Gong ; chygong14@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Targeting ; Anticancer ; Nanoparticles ; Internalization enhancement
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：135
- 期：Complete
- 页码：56-72
- 全文大小：3457 K
文摘
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Targeting ligands enhance internalization of polymeric nanoparticles in cancer cells.
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TAT is exposed by shield/deshielding mechanism to avoid non-specific binding.
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Tumor pH actives ligand-mediated delivery for tumor targeting.
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Tumor pH triggers charge conversion to tumor cell uptake.
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Polymeric nanoparticles have the potential to overcome resistance.