Common pathways regulate Type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells
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- 作者：Cynthia R. Clark
- 关键词：βArr2 ; beta-arrestin2 ; ALK ; activin receptor-like kinases ; AV ; atrioventricular ; BMP ; bone morphogenetic protein ; ca ; constitutively active ; EMT ; Epithelial&ndash ; Mesenchymal Transformation ; FGF ; fibroblast growth factor ; GFP ; green fluorescent protein ; GIPC ; GAIP-interacting protein ; C terminus ; IκB ; inhibitor of kappa B protein ; IKK ; I kappa B kinase ; NF-κB ; nuclear factor-kappa B ; qRT-P SMαA ; smooth muscle alpha actin ; TGFβ ; Transforming Growth Factor Beta ; TGFβR1 ; Type I TGFβ receptor ; TGFβR
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：28
- 期：6
- 页码：688-698
- 全文大小：1697 K
文摘
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- <p id="p0005">A TGFβR3 mutant (TGFβR3-T841A) initiates ligand-independent invasion.p>
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- <p id="p0010">Epicardial and endocardial cell invasion requires activation of the NF-κB pathway.p>
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- <p id="p0015">ALKs mediate both ligand-dependent and ligand-independent invasion.p>
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- <p id="p0020">NFκB and ALK pathways may interact but both are independently required for invasion.p>
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