Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and ¹O₂ generation

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• 作者：Jie Pan^a ; Lijun Jiang^a ; Chi-Fai Chan^a ; Tik-Hung Tsoi^b ; Kwok-Keung Shiu^a ; ; Daniel W.J. Kwong^a ; ; Wing-Tak Wong^b ; ; Wai-Kwok Wong^a ; ^{wkwong@hkbu.edu.hk} ; Ka-Leung Wong^a ; ^{klwong@hkbu.edu.hk}
• 关键词：Luminescent material ; Fluorescence probe ; Porphyrin ; Photodynamic therapy ; Ruthenium
• 刊名：Journal of Luminescence
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：184
• 期：Complete
• 页码：89-95
• 全文大小：1941 K
• 卷排序：184

文摘

Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation.