Multicomponent assembly of novel antiproliferative steroidal dihydropyridinyl spirooxindoles
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- 作者：Yan-Ling Zhanga ; b ; 1 ; Ya-Fei Lia ; 1 ; Jun-Wei Wanga ; Bin Yua ; Yun-Kai Shia ; Hong-Min Liua ; liuhm@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multicomponent assembly ; Spirooxindoles ; Dihydropyridine ; Cytotoxicity
- 刊名：Steroids
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：22-28
- 全文大小：664 K
文摘
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Multicomponent assembly of steroidal dihydropyridinyl spirooxindoles is described.
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The protocol formed two C–C bonds, two C–N bonds, and an all-carbon quaternary stereogenic center in a single operation.
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Some of these compounds were more potent than 5-FU.
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Compound 5o represented excellent inhibitory effect toward EC-109 (IC50 = 0.32 μM).