Effects of luteolin and quercetin 3-β-d-glucoside identified from Passiflora subpeltata leaves against acetaminophen induced hepatotoxicity in rats

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• 作者：Saravanan Shanmugam^a ; ^{saranflora04@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Parimelazhagan Thangaraj^b ; ^{drparimel@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bruno dos Santos Lima^a ; Rahul Chandran^b ; Adriano Antunes de Souza Araú ; jo^a ; Narendra Narain^c ; Mairim Russo Serafini^a ; Lucindo José ; Quintans Jú ; nior^a
• 关键词：Passiflora subpeltata ; Acetaminophen ; Hepatoprotective ; Luteolin ; Quercetin 3-β-d-glucoside
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：83
• 期：Complete
• 页码：1278-1285
• 全文大小：1313 K

文摘

Passiflora subpeltata has many beneficial effects in the treatment of various diseases including inflammation, pain and fever. This study was aimed to analyze the phytochemical compounds present in acetone extract of P. subpeltata leaves and to evaluate their performance against paracetamol induced hepatotoxicity activity. HPLC-DAD method was used to identify and quantify the phytochemical compounds. Hepatoprotective activity of acetone extract in the treatment of rat liver functions was monitored by the measurement of blood parameters and serum biochemical parameters such as SGOT, SGPT, ALP and in vivo antioxidant parameters viz. SOD, CAT and LPO. Further, liver tissues were also subjected to histopathological analysis. The HPLC-DAD results showed the luteolin and quercetin 3-β-d-glucoside as newly identified compounds in P. subpeltata species. Pre-treatment with acetone extract of P. subpeltata leaves at 200 and 400 mg/kg doses significantly elevated the WBC, RBC and HB counts and retained the serum biochemical and enzymatic antioxidants levels to normal level. Based on this detailed study we conclude that acetone extract of P. subpeltata leaves offered better protection against hepatotoxicity induced by the acetaminophen.