Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro

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• 作者：Andrew D. Gilley^a ; Hale Cigdem Arca^b ; Brittany L.B. Nichols^d ; Laura I. Mosquera-Giraldo^e ; Lynne S. Taylor^e ; Kevin J. Edgar^b ; ^c ; Andrew P. Neilson^a ; ^{andrewn@vt.edu}
• 关键词：Quercetin (PubChem CID ; 5280343) ; hydroxypropylmethylcellulose acetate succinate (PubChem CID ; 121950) ; polyvinylpyrrolidone (PubChem CID ; 6917)
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：86-93
• 全文大小：1833 K
• 卷排序：157

文摘

Amorphous solid dispersion with cellulose esters enhances quercetin dissolution. Polymer/quercetin 9:1 ratio was ideal for dissolution enhancement. Novel polymer cellulose acetate suberate provided optimal dissolution enhancement. Blending with polyvinylpyrrolidone enhanced cellulose acetate suberate effectiveness.