Monday preference in onset of takotsubo cardiomyopathy

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• 作者：Roberto Manfredini ; Rodolfo Citro ; Mario Previtali ; Olga Vriz ; Quirino Ciampi ; Marco Pascotto ; Ercole Tagliamonte ; Gennaro Provenza ; Fabio Manfredini ; Eduardo Bossone ; for the Takotsubo Italian Netwo
• 刊名：The American Journal of Emergency Medicine
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：28
• 期：6
• 页码：715-719
• 全文大小：151 K

文摘

Objective

Acute cardiovascular events show definite temporal patterns of occurrence. Takotsubo cardiomyopathy (TTC) has been recently shown to exhibit a seasonal (summer) and circadian (morning) temporal distribution. The aim of this study, based on the database of a multicenter Italian network, was to investigate the possible existence of a weekly pattern of onset of TTC.

Methods

The study included all cases of TTC admitted to the coronary care unit of 8 referral cardiac centers in Italy (five in Southern Italy and three in Northern Italy, respectively), belonging to the Takotsubo Italian Network (January 2002-December 2008). Day of admission was categorized into seven 1-day intervals according by week, and chronobiological analysis was performed by partial Fourier series.

Results

The database included 112 patients with TTC (92.9 % females). The weekly distribution identified the highest number of cases on Monday and the lowest on Saturday. Chronobiologic analysis yielded a rhythmic pattern with a significant peak on Monday (P = .036).

Conclusions

This study confirms a Monday preference for TTC occurrence on Monday, similar to that reported for acute myocardial infarction. Stress of starting weekly day life activities, could play a triggering role.