Chronic blockade of the AT2 receptor with PD123319 impairs insulin signaling in C57BL/6 mice

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• 作者：M.C. Muñ ; oz ; V. Burghi ; J.G. Miquet ; I.A. Cervino ; D.T. Quiroga ; L. Mazziotta ; F.P. Dominici ; ^{dominici@qb.ffyb.uba.ar} ; ^{fernando.dominici@hotmail.com}
• 关键词：Angiotensin II ; Angiotensin type 2 receptor ; Glucose tolerance ; Insulin ; Renin-angiotensin system
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：37-45
• 全文大小：2057 K
• 卷排序：88

文摘

AT2R antagonism attenuated insulin signaling in both liver and adipose tissue. ERK 1/2 might participate in the attenuation of insulin signaling in the liver. Current results suggest a role for the AT2R in the control of insulin action.