Cytotoxic prenylated flavonoids from Morus alba

详细信息    查看全文

• 作者：Nguyen Tien Dat ; Phung Thi Xuan Binh ; Le Thi Phuong Quynh ; Chau Van Minh ; Hoang Thanh Huong ; Jung Joon Lee
• 关键词：Morus alba ; Moraceae ; Prenylated flavonoid ; Morusin ; Cytotoxicity
• 刊名：Fitoterapia
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：81
• 期：8
• 页码：1224-1227
• 全文大小：327 K

文摘

A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1–11). The structure of the new 3′-geranyl-3-prenyl-2′,4′,5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC₅₀ value of 0.64 μM against HeLa cells.