Interferon alfa-2a in Japanese encephalitis: a randomised double-blind placebo-controlled trial

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• 作者：Solomon ; Tom ; Dung ; Nguyen Minh ; Wills ; Bridget ; Kneen ; Rachel ; Gainsborough ; Mary ; Diet ; Tran Vinh ; et. al.
• 刊名：The Lancet
• 出版年：2003
• 出版时间：March 8, 2003
• 年：2003
• 卷：361
• 期：9360
• 页码：821-826
• 全文大小：91.0 K

文摘

Background Japanese encephalitis virus (JEV), although confined to Asia, causes about 35 000–50 000 cases and 10 000 deaths every year, and is the most important cause of encephalitis worldwide. There is no known antiviral treatment for any flavivirus. Results from in-vitro studies and work in animals have shown inteferon alfa has antiviral activity on Japanese encephalitis and other flaviviruses; therefore, we aimed to assess the efficacy of inteferon alfa-2a in Japanese encephalitis.