Vasospasm after subarachnoid hemorrhage in haptoglobin 2-2 mice can be prevented with a glutathione peroxidase mimetic

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• 作者：Michael T. Froehler ; Ali Kooshkabadi ; Rachel Miller-Lotan ; Shany Blum ; Slava Sher ; Andrew Levy ; Rafael J. Tamargo
• 关键词：Glutathione peroxidase ; Haptoglobin ; Subarachnoid hemorrhage ; Vasospasm
• 刊名：Journal of Clinical Neuroscience
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：17
• 期：9
• 页码：1169-1172
• 全文大小：406 K

文摘

Vasospasm after subarachnoid hemorrhage (SAH) is attributable to inflammation and oxidative stress associated with extracellular hemoglobin (Hb). Haptoglobin (Hp) binds free Hb and the Hp–Hb complex is cleared by macrophages, and the Hp-2 isoform of Hp is associated with more oxidative stress and more severe vasospasm. We hypothesized that treatment with an anti-oxidant, the glutathione peroxidase mimetic SYI-2074, would reduce vasospasm after SAH in Hp-2 mice. We found that SAH induced significant vasospasm in Hp-2 mice (lumen patency reduced to 65.9 % ), but no vasospasm was seen in mice that received SYI-2074 after SAH (lumen patency of 98.7 % ). We conclude that vasospasm after SAH in Hp-2 mice can be prevented with SYI-2074, suggesting that oxidative stress contributes significantly to vasospasm.