Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses

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• 作者：Jardin A. Leleux¹ ; ^{jleleux3@gatech.edu} ; Pallab Pradhan¹ ; ^{ppiitb@gmail.com} ; Krishnendu Roy¹ ; ² ; ^{krish.roy@gatech.edu}
• 关键词：TLR9 ; dendritic cells ; PAMP ; adjuvant density ; vaccines ; PLGA ; immunotherapy ; immune modulation ; vaccine delivery ; adjuvant delivery
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：700-710
• 全文大小：3177 K
• 卷排序：18

文摘

Biophysical attributes of particles can modulate TLR9 signaling in dendritic cells The density of CpG on particle carriers affects signaling along the TLR9-MyD88-NF-κB axis Particle parameters affect STAT3 phosphorylation, regulating dendritic cell signaling Physical pattern-driven dendritic cell programming skews in vivo immune polarization