Radiolytic studies of cefozopran hydrochloride in the solid state

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• 作者：Przemysław Zalewski^a ; Robert Skibiński^b ; Daria Szymanowska-Powałowska^c ; ^{darszy@up.poznan.pl} ; Hanna Piotrowska^d ; Waldemar Bednarski^e ; Judyta Cielecka-Piontek^a
• 关键词：Antibacterial prophylaxis ; Beta radiation ; Cephalosporin ; Cytotoxicity ; Drug sterilization ; Electron paramagnetic resonance spectroscopy ; EPR spectra ; Ionizing radiation ; Microbiological activity ; Q-TOF ; Radiation sterilization ; Thermolabile drugs
• 刊名：Electronic Journal of Biotechnology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：25
• 期：Complete
• 页码：28-32
• 全文大小：455 K
• 卷排序：25

文摘

The radiation sterilization is one of the best methods for sterilizing vulnerable degradation drugs like cefozopran hydrochloride.ResultsChemical stability of radiosterylized cefozopran hydrochloride, was confirmed by spectrophotometric and chromatographic methods. EPR studies showed that radiation has created some radical defects whose concentration was no more than several dozen ppm. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy was unaltered for Gram-positive bacteria but changed for two Gram-negative strains. The radiation sterilized cefozopran hydrochloride was not in vitro cytotoxic against human CCD39Lu normal lung fibroblast cell line.ConclusionsCefozopran hydrochloride in solid state is not resistant to radiation sterilization and this method cannot be used for sterilization of this compound.