p62 modulates the intrinsic signaling of UVB-induced apoptosis
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- 作者：Sachiko Itoa ; Shintaro Kimurab ; Eiji Warabic ; Yasuhiro Kawachid ; Masanobu Yamatojie ; Fumihiko Uchidae ; Naomi Ishibashi-Kannoe ; Kenji Yamagatae ; Shogo Hasegawae ; Junichi Shodaf ; Katsuhiko Tabuchig ; Satoshi Sakaih ; Hiroki Bukawae ; Mitsuru Sekidoi ; Toru Yanagawae ; ytony@md.tsukuba.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROS ; reactive oxygen species ; UV ; ultraviolet ; PCR ; polymerase chain reaction ; MEF ; mouse embryo fibroblast ; RIPA buffer ; radioimmunoprecipitation assay buffer ; PVDF ; polyvinylidene difluoride ; PI ; propidium iodide ; Bcl-2 ; B-cell lymphoma 2 ; Bcl-xL ; B-cell lymphoma-extra large ; Bax ; Bcl-2&ndash ; associated X protein ; PUMA ; p53 upregulated modulator of apoptosis ; Noxa ; Phorbol-12-myristate-13-acetate-induced protein 1 ; ATM ; Ataxia telangiectasia mutated ; ATR ; ATM- and RAD3-related ; Stat3 ; signal t
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：83
- 期：3
- 页码：226-233
- 全文大小：1695 K
文摘
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P62-deficient cells are more resistant to UVB-induced apoptosis than normal cells.
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Bcl-2 family expression and Stat3 phosphorylation are changed in p62-deficient cells.
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P62 modulates the intrinsic signaling pathway of UVB-induced apoptosis.