Simulated moving bed chromatography for the separation of enantiomers

详细信息    查看全文

• 作者：Arvind Rajendran ; Galatea Paredes ; Marco Mazzotti
• 关键词：Simulated moving bed chromatography ; Enantiomer separations ; Triangle theory ; Simulation and optimization ; Equilibrium theory
• 刊名：Journal of Chromatography A
• 出版年：2009
• 出版时间：23 January 2009
• 年：2009
• 卷：1216
• 期：4
• 页码：709-738
• 全文大小：2351 K

文摘

Simulated moving bed (SMB) chromatography, a continuous multi-column chromatographic process, has become one of the preferred techniques for the separation of the enantiomers of a chiral compound. Several active pharmaceutical ingredients, including blockbuster drugs, are manufactured using the SMB technology. Compared to single column preparative chromatography, SMB separations achieve higher productivity and purity, while reducing the solvent consumption. The SMB technology has found applications both at small and large scales. Design methods have been developed for robust operation and scale-up, using data obtained from analytical experiments. In the last few years, rapid developments have been made in the areas of design, improved process schemes, optimization and robust control. This review addresses these developments, as well as both the fundamentals of the SMB science and technology and some practical issues concerning the operation of SMB units. Particular emphasis is placed on the consolidation of the “triangle theory”, a design tool that is used both in the academia and industry for the design of SMB processes.