Electro-oxidation and determination of gabapentin at gold electrode

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• 作者：Rajesh N. Hegde^a ; B.E. Kumara Swamy^b ; Nagaraj P. Shetti^a ; Sharanappa T. Nandibewoor^a ; ^{stnandibewoor@yahoo.com}
• 关键词：Gabapentin ; Voltammetry ; Gold electrode ; Drug analysis ; Oxidation
• 刊名：Journal of Electroanalytical Chemistry
• 出版年：2009
• 出版时间：1 October 2009
• 年：2009
• 卷：635
• 期：1
• 页码：51-57
• 全文大小：753 K

文摘

The electrochemical oxidation of gabapentin has been investigated for the first time by cyclic, linear sweep and differential-pulse voltammetry at different pH at gold electrode. Cyclic voltammetric studies were performed in a wide range of sweep rates and various concentrations of gabapentin. The effect of surfactants was studied. The anodic peak was characterized and process was adsorption-controlled. The oxidation peak corresponds to the amine and probable mechanism was proposed. According to the linear relation between the peak current and the gabapentin concentration, differential-pulse voltammetric method for the quantitative determination in pharmaceuticals was developed. The linear response was obtained in the range of 0.3?5 ¦ÌM with a detection limit of 0.13 ¦ÌM with good selectivity and sensitivity. The proposed method was successfully applied to gabapentin determination in pharmaceutical samples and for the detection of gabapentin in urine as a real sample.