The clinical significance of cereblon expression in multiple myeloma
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- 作者：Steven R. Schuster ; K. Martin Kortuem ; Yuan Xiao Zhu ; Esteban Braggio ; Chang-Xin Shi ; Laura A. Bruins ; Jessica E. Schmidt ; Greg Ahmann ; Shaji Kumar ; S. Vincent Rajkumar ; Joseph Mikhael ; Betsy LaPlant ; Mia D. Champion ; Kristina Laumann ; Bart Barlogie ; Rafael Fonseca ; P. Leif Bergsagel ; Martha Lacy ; A. Keith Stewart
- 关键词：Multiple myeloma ; Cereblon ; Gene expression profiling ; Immunomodulatory drugs ; Biological markers
- 刊名：Leukemia Research
- 出版年：January, 2014
- 年：2014
- 卷：38
- 期：1
- 页码：23-28
- 全文大小：1772 K
文摘
Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). We demonstrate here that no patient with very low CRBN expression responded to IMiD plus dexamethasone therapy. In 53 refractory MM patients treated with pomalidomide and dexamethasone, CRBN levels predict for decreased response rates and significant differences in PFS (3.0 vs. 8.9 months, p < 0.001) and OS (9.1 vs. 27.2 months, p = 0.01) (lowest quartile vs. highest three quartiles). While higher CRBN levels can serve as a surrogate for low risk disease, our study demonstrates that low CRBN expression can predict resistance to IMiD monotherapy and is a predictive biomarker for survival outcomes.