Prophylactic potential of resiquimod against very virulent infectious bursal disease virus (vvIBDV) challenge in the chicken
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- 作者：Arunsaravanakumar Annamalaia ; 1 ; Saravanan Ramakrishnana ; 1 ; dearsaromib@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Swati Sachana ; B.S. Anand Kumara ; Bal Krishan Sharmaa ; Vimal Kumara ; Munuswamy Palanivelub ; Berin P. Vargheseb ; Ajay Kumarc ; B.C. Saravanand ; Narayanan Krishnaswamye
- 关键词：Toll-like receptors ; Prophylaxis ; Real time PCR ; Infectious bursal disease ; Resiquimod ; Immune response genes ; Chicken
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：187
- 期：Complete
- 页码：21-30
- 全文大小：2154 K
文摘
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Prophylactic role of resiquimod (R-848) against vvIBDV was evaluated in chicken.
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R-848 apparently reduced the mortality and bursal damage.
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IBDV antigen clearance from the bursa was evident in R-848 pre-treated birds.
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R-848 conferred complete protection against the vvIBDV induced immunosuppression.
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R-848 significantly induced the transcripts of immune response genes post-challenge.