Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis
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- 作者：Chi-Yeh Chung1 ; 2 ; 5 ; Zhen Sun1 ; 3 ; 5 ; Gavriel Mullokandov2 ; 5 ; Almudena Bosch4 ; Zulekha A. Qadeer1 ; 5 ; Esma Cihan1 ; Zachary Rapp1 ; Ramon Parsons1 ; 5 ; Julio A. Aguirre-Ghiso5 ; 6 ; Eduardo F. Farias6 ; Brian D. Brown2 ; 5 ; Alexandre Gaspar-Maia1 ; alexandre.maia@mssm.edu" class="auth_mail" title="E-mail the corresponding author ; Emily Bernstein1 ; 5 ; emily.bernstein@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：16
- 期：2
- 页码：472-486
- 全文大小：3358 K
文摘
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RNAi screen in sphere culture identifies Cbx8 in promoting breast cancer
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Cbx8 is upregulated in human breast cancer and correlates with poor survival
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Cbx8 promotes mammary tumors in vivo via Notch pathway activation
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Cbx8 cooperates with Wdr5 to sustain Notch expression by regulating H3K4me3