Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice

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• 作者：Lin Zhang^a ; ^b ; Xiaozhi Liu^a ; ^b ; Huaxin Sheng^a ; Shuai Liu^a ; Ying Li^a ; ^c ; Julia Q. Zhao^a ; David S. Warner^a ; Wulf Paschen^a ; ^{wulf.paschen@duke.edu} ; Wei Yang^a ; ^{wei.yang@duke.edu}
• 关键词：ANOVA ; analysis of variance ; Arc ; activity-regulated cytoskeleton-associated protein ; GFP ; green fluorescent protein ; GO ; gene ontology ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; MAPK ; mitogen-activated protein kinase ; miRNA ; microRNA ; OGD ; oxygen/glucose deprivation ; PCA ; principal component analysis ; qPCR ; quantitative real-time PCR ; RanGAP1 ; Ran GTPase-activating protein-1 ; rCBF ; regional cerebral blood flow ; SUMO ; small ubiquitin-like modifier ; SUMO-KD ; SUMO1-3 knockdown ; WI ; wild-type
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：190-212
• 全文大小：2543 K
• 卷排序：343

文摘

SUMOylation suppresses gene expression in the brain in the physiologic state. SUMOylation promotes global gene expression response to ischemia in the brain. SUMOylation assists in recovery of neurologic function after brain ischemia.