Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance
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- 作者：Tineke Cantaert1 ; 10 ; Jean-Nicolas Schickel1 ; 10 ; Jason M. Bannock1 ; Yen-Shing Ng1 ; Christopher Massad1 ; Tyler Oe1 ; Renee Wu1 ; Aubert Lavoie2 ; Jolan E. Walter3 ; 4 ; Luigi D. Notarangelo4 ; Waleed Al-Herz5 ; Sara Sebnem Kilic6 ; Hans D. Ochs7 ; Shigeaki Nonoyama8 ; Anne Durandy9 ; Eric Meffre1 ; eric.meffre@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：activation-induced cytidine deaminase ; B cell development ; B cell tolerance ; AID-deficient patients
- 刊名：Immunity
- 出版年：2015
- 出版时间：17 November 2015
- 年：2015
- 卷：43
- 期：5
- 页码：884-895
- 全文大小：3959 K
文摘
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AID is co-expressed with RAG2 in some bone marrow immature B cells
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Most AID+ immature B cells also co-expressed BCL6 like germinal center B cells
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AID+ immature B cells lack anti-apoptotic MCL-1 and are deleted by apoptosis
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B cell intrinsic AID expression mediates central B cell tolerance