Synthesis of methyl ketones from terminal olefins using PdCl₂/CrO₃ system mimicking the Wacker process

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• 作者：Rodney A. Fernandes ; ^{rfernand@chem.iitb.ac.in" class="auth_mail} ; Venkati Bethi
• 关键词：Homogenous catalysis ; Oxidation ; Palladium complexes ; Wacker-type reaction
• 刊名：Tetrahedron
• 出版年：12 August 2014
• 年：2014
• 卷：70
• 期：32
• 页码：4760-4767
• 全文大小：854 K

文摘

An efficient synthesis of methyl ketones from terminal olefins using PdCl₂/CrO₃ system mimicking the Wacker process is developed. The method shows good functional groups compatibility, no aldehyde by-products and is operationally simple. CrO₃ is the sole oxidant and replaces both Cu-salts and molecular oxygen, traditionally used in this process. The method holds potential for future applications in organic synthesis.