New efficient synthesis of multisubstituted benzimidazoles and quinoxalin-2(1H)-ones by a Ugi 4CC/aza-Wittig sequence starting from aromatic amine precursors

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• 作者：Yan-Mei Yan ; Yun Gao ; Ming-Wu Ding ; ^{mwding@mail.ccnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ugi reaction ; aza-Wittig reaction ; CH activation ; Benzimidazole ; Quinoxalin-2(1H)-one
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：1 September 2016
• 年：2016
• 卷：72
• 期：35
• 页码：5548-5557
• 全文大小：583 K

文摘

An efficient preparation of multisubstituted benzimidazoles and quinoxalin-2(1H)-ones by Ugi 4CC/aza-Wittig sequence was developed. The 2-azidobenzenamines, obtained from CH activation of aromatic amine precursors, reacted with aldehydes, acids, and isocyanides to produce Ugi products, which were transformed to the benzimidazoles or quinoxalin-2(1H)-ones in moderate to good yields in further reaction with triphenylphosphine.