Stereoselective synthesis of indenone-fused heterocyclic compounds via a one-pot four-component reaction

详细信息    查看全文

• 作者：Mohammad Bayat^a ; ^{bayat_mo@yahoo.com} ; ^{m.bayat@sci.ikiu.ac.ir} ; Fahimeh Sadat Hosseini^a ; Behrouz Notash^b
• 关键词：Diamines ; 1 ; 1-bis(methylthio)-2-nitroethene ; 1 ; 3-indandione ; Aromatic aldehydes ; Multi-component synthesis
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：23 February 2017
• 年：2017
• 卷：73
• 期：8
• 页码：1196-1204
• 全文大小：3111 K
• 卷排序：73

文摘

A one-pot multi-component synthesis of indenone-fused heterocyclic derivatives from readily available starting materials including diamines, 1,1-bis(methylthio)-2-nitroethene, 1,3-indandione and aromatic aldehydes in excellent yields is described. The sequence of cascade reactions include Knoevenagel condensation, enamine formation, Michael addition, imine-enamine tautomerization and cyclization. The diastereoselective synthesis of cis-indenohydropyridine have been definitively proven by X-ray crystallography.