Adrenocortical sensitivity, moderated by ongoing stress, predicts drinking intensity in alcohol-dependent men

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• 作者：Bryon Adinoff^a ; ^b ; ^{Bryon.adinoff@utsouthwestern.edu} ; David Leonard^c ; Julianne Price^b ; Martin A. Javors^d ; Robrina Walker^b ; E. Sherwood Brown^b ; Hong Xiao^e ; Uma Rao^f ; ^g
• 关键词：Alcoholism ; HPA ; Stress ; Relapse ; Cortisol
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：67-76
• 全文大小：1657 K
• 卷排序：76

文摘

Allostatic load from stress and cortisol secretion may worsen course of alcoholism. Effects of HPA axis activity and ongoing stress upon drinking severity were assessed. Life stress and drinking assessed biweekly for 6 months post-treatment discharge. Adrenocorticoid reactivity, moderated by stress, predicted drinking intensity. Addressing both glucocorticoid and stress reactivity may lessen relapse severity.