Cu(I)-catalyzed one-pot decarboxylation-alkynylation reactions on 1,2,3,4-tetrahydroisoquinolines and one-pot synthesis of triazolyl-1,2,3,4-tetrahydroisoquinolines
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- 作者：Birgit Grö ; ll ; Patricia Schaaf ; Marko D. Mihovilovic ; Michael Schnü ; rch ; michael.schnuerch@tuwien.ac.at
- 关键词：Click reaction ; Copper catalysis ; Cross dehydrogenative coupling ; One-pot reaction ; Domino catalysis
- 刊名：Journal of Molecular Catalysis A: Chemical
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：426
- 期：part_PB
- 页码：398-406
- 全文大小：755 K
- 卷排序：426
文摘
Short chained alkynes can be introduced without the need for gaseous reagents by using the corresponding alkynoic acids. Alkynylations with alkynoic acids work in good yields independent of the chain length and protecting group of the substrate. A three step cascade of decarboxylation, alkynylation, and click reaction was developed using the same catalyst, namely CuCl.