NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats
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- 作者：Hisakazu Izumidaa ; Hiroshi Takagia ; Haruki Fujisawaa ; Naoko Iwataa ; Kohtaro Nakashimaa ; Seiji Takeuchia ; Shintaro Iwamaa ; Takashi Nambab ; Yukio Komatuc ; Kozo Kaibuchib ; Yutaka Oisoa ; Hiroshi Arimaa ; Yoshihisa Sugimuraa ; sugiyosi@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hyponatremia ; Adrenal insufficiency ; NMDA receptor antagonist ; Memantine ; Cell death ; Apoptosis ; Hippocampal dentate gyrus ; Basal synaptic transmission ; Long term potentiation
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：65-74
- 全文大小：1508 K
文摘
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Reduced serum [Na+] was associated with apoptosis in the DG in ADX rats.
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Impaired synaptic transmission was also observed in the DG in hyponatremic ADX rats.
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These effects were reversed by therapeutically relevant doses of memantine.