Methylphenidate amplifies long-term potentiation in rat hippocampus CA1 area involving the insertion of AMPA receptors by activation of β-adrenergic and D1/D5 receptors
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- 作者：C. Rozasa ; 1 ; C. Carvalloa ; 1 ; D. Contrerasa ; M. Carreñ ; oa ; G. Ugartea ; R. Delgadoa ; M.L. Zeiseb ; B. Moralesa ; bernardo.morales@usach.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：MPH ; D1/D5 receptors ; Glutamate receptors ; Hippocampus ; LTP
- 刊名：Neuropharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：99
- 期：Complete
- 页码：15-27
- 全文大小：2397 K
文摘
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Methylphenidate (MPH) augments electrically induced LTP in the rat hippocampus (CA1).
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It does so via β-adrenergic and D1/D5 receptors activation.
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The increase of LTP by MPH involves the activation of the cAMP-PKA dependent cascade.
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MPH promotes AMPA receptor trafficking by phosphorylation of the S845 GluR1 subunit.
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MPH promotes the insertion of functional AMPA receptors in the plasma membrane.