Endothelial cells regulate β-catenin activity in adrenocortical cells via secretion of basic fibroblast growth factor

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• 作者：Carolin Schwafertz^a ; Sven Schinner^a ; Markus C. Kü ; hn^a ; Matthias Haase^a ; ^b ; Amelie Asmus^a ; Birgit Mü ; lders-Opgenoorth^a ; Ishrath Ansurudeen^b ; ^c ; Peter J. Hornsby^d ; Henning Morawietz^b ; Elke Oetjen^e ; Matthias Schott^a ; Holger S. Willenberg^a ; ^f ; ^{Holger.Willenberg@uni-rostock.de}
• 关键词：Aldosterone ; Adrenal gland ; Beta-catenin ; Basic fibroblast growth factor ; CITED2
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：441
• 期：Complete
• 页码：108-115
• 全文大小：1748 K
• 卷排序：441

文摘

Endothelial cells induce β-catenin activity in adrenal cortical cells. Wnt-signaling, cAMP, Akt or PKC pathways are not involved. MEK, PI3-kinase and receptor tyrosine kinases are involved. Stimulation of β-catenin and StAR activity is partly mimicked by bFGF. bFGF is produced and secreted by human umbilical cord endothelial cells.