ErbB2 is required for cardiomyocyte proliferation in murine neonatal hearts
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- 作者：Hong Ma ; Chaoying Yin ; Yingao Zhang ; Li Qian ; Jiandong Liu ; jiandong_liu@med.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atm ; ATM serine/threonine kinase ; Bax ; BCL2-associated x protein ; Casp3 ; caspase 3 ; CDK ; cyclin-dependent kinases ; CDKIs ; CDK inhibitors ; Cdkn3 ; cyclin-dependent kinase inhibitor 3 ; Cko ; cardiac conditional knockout ; CM ; cardiomyocyte ; ErbB2 ; erb-b2 receptor tyrosine kinase 2 ; ErbB4 ; erb-b2 receptor tyrosine kinase 4 ; Gapdh ; glyceraldehyde-3-phosphate dehydrogenase ; Nrg1 ; neuregulin1 ; Rbl1 ; retinoblastoma-like 1 ; Trp53 ; tumor protein p53
- 刊名：Gene
- 出版年：2016
- 出版时间：5 November 2016
- 年：2016
- 卷：592
- 期：2
- 页码：325-330
- 全文大小：916 K
文摘
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Cardiac ErbB2 exhibited a steep decrease in expression from embryonic to postnatal stage.
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ErbB2 is required for neonatal cardiomyocyte proliferation in murine.
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ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.