In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats
详细信息 查看全文
- 作者：Andrea Cabrera-Pastor ; Vicente Hernandez-Rabaza ; Lucas Taoro-Gonzalez ; Tiziano Balzano ; Marta Llansola ; Vicente Felipo ; vfelipo@cipf.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Extracellular cGMP ; Neuroinflammation ; Spatial learning ; IL-1β ; TNF-α ; NMDA receptors ; AMPA receptors ; Membrane expression ; Working memory ; Reference memory
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：360-370
- 全文大小：3696 K
文摘
- •
Neuroinflammation alters working and reference memory by different mechanisms.
- •
IL-1β alters hippocampal NMDA receptor membrane expression impairing working memory.
- •
TNF-α alters AMPA receptor membrane expression impairing spatial reference memory.
- •
Extracellular cGMP reverses the effects on TNF-α, AMPA receptor and reference memory.
- •
Extracellular cGMP does not restore IL-1β, NMDA receptors or working memory.