Relief learning requires a coincident activation of dopamine D1 and NMDA receptors within the nucleus accumbens

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• 作者：Jorge R. Bergado Acosta^a ; Evelyn Kahl^a ; Georgios Kogias^a ; ^b ; Taygun C. Uzuneser^a ; ^b ; ¹ ; Markus Fendt^a ; ^c ; ^{markus.fendt@med.ovgu.de}
• 关键词：Conditioning ; Dopamine ; NMDA receptor ; Nucleus accumbens ; Relief learning ; Startle response
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：58-66
• 全文大小：1666 K
• 卷排序：114

文摘

Backward pairing of CS and US leads to relief learning. Nucleus accumbens dopamine D1 receptors are involved in relief learning. Low doses of a D1 or NMDA antagonist, injected alone, do not affect relief learning. Combined injections of low doses of a D1 or NMDA antagonist block relief learning. This indicates that a coincident D1/NMDA activation is crucial for relief learning.